"Among people who are prescribed opioids, addiction is relatively uncommon. The percentage of patients who become addicted after taking opioids for chronic pain is measured in the single digits; studies show an incidence from less than 1 percent to 8 percent. Most of the estimates are skewed toward the low end of this range, when those at risk (due to a history of substance abuse or, to a lesser but meaningful extent, a concurrent mental illness) are removed from the sample. In Feldman’s case, the nature of the risk was constant anguish. When she was 4 years old, her heroin-addicted mother left the family and died of an overdose before she was 12. “For so much of my childhood, I felt abandoned, worthless, unlovable, and confused,” she told me. Her first Percocet came from a girlfriend. “Being numb helped,” she said. Before Percocet, though, she had achieved “escape” with marijuana, alcohol, PCP, benzodiazepines, and cocaine."